Prevent neurodegenerative diseases! Drink coffee like this to stay away from dementia and Parkinson’s disease

【早安健康/張金堅、蔡崇煌醫師】
咖啡與神經系統疾病(neurological diseases)

一般大眾咸認為一口氣喝200毫克咖啡因(約2.5杯咖啡),或一天飲用量不超過400毫克的咖啡因(5杯), 對身體就沒有傷害,且對於腦部神經系統的警覺性和健康、集中注意力具有幫助,並能夠降低憂鬱症風險,以及強化藥物對頭痛的作用等。

長期服用咖啡或咖啡因可防止認知能力下降,並可降低中風、巴金森氏症和阿茲海默症的風險,但可能會提高某些人的焦慮及擾亂睡眠。

在癲癇方面,咖啡的作用目前尚有爭議,在動物模型研究,發現短期服用咖啡因會降低癲癇的閾值,使較易發作,但相反地,在人的研究發現長期服用咖啡/咖啡因,可減少癲癇發作及減低癲癇重積狀態(status epilepticus)時的腦損傷。

咖啡豆醇(kahweol)可以保護神經細胞不被傷害,例如可保護導致巴金森氏症有關的神經毒素6-羥基多巴胺(6-hydroxydopamine;6-OHDA)神經元細胞免於死亡。研究發現咖啡豆醇能經由磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase;PI3K)和p38 / Nrf2的途徑,誘導血紅素原加氧酶-1(heme oxygenase-1),經由6-羥基衍生的氧化壓力(6-hydroxydopamine-derived oxidative stress),以保護多巴胺神經元。

咖啡藉由多重機轉降低巴金森氏症的相對風險

巴金森氏症(Parkinson’s disease)是發病率僅次於阿茲海默症的神經退化性疾病,病因仍然不明, 但與因大腦黑質腦細胞退化,無法製造足夠的多巴胺(dopamine)有關。

為什麼黑質細胞會退化呢?目前還不清楚,據推測,可能與基因、環境或生活因素有關,例如濫用抗生素、重金屬污染等。最近好幾個研究都顯示喝咖啡,竟然可預防巴金森氏症。

60∼80%的巴金森氏症患者都有便秘問題,而且是早在病徵出現的10∼20年前就開始。2014年,臺大醫院神經部的團隊分析健保資料庫中55萬個巴金森氏症病例,也再度證實有便秘困擾的人日後得到巴金森氏症的機率比一般人高出許多,而且便秘越嚴重,機率越高。

((降低失智風險要喝幾杯咖啡好?答案就在下一頁))

Drinking coffee daily can interfere with brain aging and reduce the risk of cognitive impairment

coffee -dementia

Don’t be afraid of caffeine! Drinking the right amount of coffee can prevent Alzheimer’s disease?

Coffee can interfere with brain aging, a few cups a day to reduce the risk of cognitive impairment by 69%

Have you had your coffee today? A sip of coffee, sweet with a bit of bitterness, this is the taste of coffee, but also the taste of life! “Coffee” always follows us to start our busy day, accompanying us to stay up late, work overtime, and also accompany us to enjoy the afternoon. In the face of the modern fear of dementia, did you know that drinking coffee may also be a preventive method?

Studies have shown that moderate caffeine intake can reduce the risk of dementia
In recent years, many studies have shown that long-term coffee consumption can help prevent Alzheimer’s disease and dementia. According to Medical Daily, a study published in The Journals of Gerontology in 2016 stated that

The study’s respondents were 6467 women aged 65 to 80, 388 of whom were diagnosed with a high risk of dementia, and the study recorded their self-reported caffeine intake for 10 consecutive years. The results found that compared to less frequent coffee drinkers (less than 64 mg of caffeine per day), more frequent coffee drinkers (more than 261 mg of caffeine per day) had a 36% lower risk of dementia.

Researchers say that the relationship between caffeine intake and dementia risk cannot be directly linked to each other, but the study points out that caffeine helps protect cognitive function because it can bind to the brain’s adenosine receptors, interfering with normal aging and aging-related pathologies to achieve health effects.
However, the women in this study had already reached menopause and were more educated, so the results may not be representative of all female populations. In addition, the researchers did not specifically account for sources of caffeine other than coffee and tea, so the actual caffeine intake of these respondents may be higher. Science Daily reported that an Italian study published in the Journal of Alzheimer’s Disease in 2015 looked at 1,445 Italians with normal cognitive function, aged 65 to 84 years old, and conducted a study on coffee consumption. The study found that the amount of coffee consumed by 1445 Italian people with normal cognitive function, aged 65 to 84 years old.

The results found that people who drank one to two cups of coffee a day for a long time had a lower risk of mild cognitive impairment (MCI) than those who never drank coffee or drank very little. Those who drank one cup a day had a 53% lower risk of MCI, and those who drank one to two cups a day had a 69% lower risk of MCI. However, there was no significant change in the risk of MCI for those who drank more than 2 cups of coffee per day compared to those who never drank or rarely drank coffee. Therefore, the researchers suggest that regular and moderate coffee consumption may help protect the nerves and reduce the risk of MCI, which supports the argument that “long-term caffeine intake helps prevent dementia” in some previous studies.

Why can coffee improve Alzheimer’s disease?

Why can coffee improve Alzheimer’s disease? Research suggests that it has to do with these two ingredients contained in coffee!

Why does coffee have these effects? Researchers believe that it may be the effect of caffeine and antioxidants. According to the science news site EurekAlert, a report presented at the 2014 Alzheimer Europe Annual Congress, caffeine can help prevent the formation of Alzheimer’s disease, and both caffeine and polyphenols can reduce the inflammation and degeneration of brain cells.

In this way, it seems that moderate coffee can really help prevent Alzheimer’s disease, dementia, which is really good news for people who love coffee! However, the more coffee you drink, the better, because too much caffeine can cause insomnia, palpitations, tremors, agitation and other symptoms, and even block the absorption of calcium.

In addition, each person can tolerate the amount of caffeine are different, some people are even more sensitive to caffeine, drink it will have a headache, so should be adjusted according to their own circumstances, do not drink exactly according to the above-mentioned studies in the amount of servings. At present, the European Commission of Food Science experts recommend that the daily intake of caffeine does not exceed 300 mg.

As for the prevention of dementia, coffee may be one of the influencing factors, but it also needs to be combined with sufficient sleep, regular exercise, balanced diet, stress relief and other good lifestyle habits in order to minimize the risk of dementia, not just rely on coffee.

In addition, it is recommended that pregnant mothers, breastfeeding mothers, people with excessive stomach acidity, and people prone to diarrhea avoid drinking coffee, and people in general should avoid drinking on an empty stomach and after exercise in order to enjoy the aroma of coffee without affecting their health.

Study: Coffee helps prevent Alzheimer’s, Parkinson’s! Which is better: dark roast or light roast?

Coffee helps prevent Alzheimer's

A new study recently found that a cup of coffee in the morning not only lifts the spirits, but also protects against Alzheimer’s and Parkinson’s disease. Researchers at the Dolan-Doklopil Brain Institute found that phenylindanes, a chemical breakdown product of chlorogenic acid lactones in roasted coffee, inhibits the growth of Tau proteins and beta amyloid plaques, two proteins associated with increased risk of two diseases in the brain.

Regular Caffeine Intake May Help Prevent Dementia

According to Alzheimer’s and Dementia Weekly, Dr. Donald Weaver, co-director of the Crumbill Brain Institute, noted that coffee consumption appears to be associated with a reduced risk of Alzheimer’s and Parkinson’s disease, and they want to investigate what the cause is, what compounds are involved, and how it affects age-related cognitive decline.

Other studies have found that regular caffeine intake may help prevent dementia, AARP said. A study published in the Journal of Alzheimer’s Disease, which looked at people aged 65 to 84, showed that people who drank one to two cups of coffee a day were less likely to have mild cognitive impairment than those who never drank coffee. The American Association of Retired Persons pointed out that similar studies have found that coffee can even prevent Parkinson’s disease.

Dark-roasted coffee is more protective than light-roasted coffee

However, Canadian researchers have ruled out caffeine as a source of brain protection because even decaffeinated roasted coffee is beneficial in preventing dementia. The team determined that phenyl lindane, obtained through roasted coffee, is a beneficial compound that inhibits the aggregation of Tau and beta amyloid proteins in the brain associated with Alzheimer’s and Parkinson’s diseases.

The researchers also found that dark-roasted coffee, which contains more phenyl lindane, was more protective than light-roasted coffee, and the next step in the study is to measure how these compounds get into the bloodstream and cross the blood-brain barrier, and the good news is that phenyl lindane is a natural compound that has medicinal advantages over synthetic products. Dr. Weaver said that before coffee can be used to treat Alzheimer’s or Parkinson’s, more research is needed.

Prevent neurodegenerative diseases! Drink coffee like this to stay away from dementia and Parkinson’s disease